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KMID : 0895820160260020001
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Journal of Oriental Rehabilitation Medicine
2016 Volume.26 No. 2 p.1 ~ p.12
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Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice
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Ye Sung-Ae
Kim Ho-Jun
Go Sung-Gyu
Song Yun-Kyung
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Abstract
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Objectives : The purpose of this study was to evaluate anti-obesity effect of Galgeuntang (gegentang) and elucidate the effect of it on gene expression related to obesity.
Methods : The experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to investigate the effect of GGT on gene expression in liver tissue.
Results : GGT group and ORL group were reduced in body weight compared with HFD. HFD increased PPARγ, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced PPARγ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD.
Conclusions : These results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future.
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KEYWORD
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Galgeun-tang, gegentang, obesity, orlistat Galgeun, Mahwang, Obesityrelated genes
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